Karki was born in a Nepalese family. Born to parents, Bhupendra Karki and Raksha Malhotra, she has a younger brother Pranit Karki who lived in the United States.
Priyanka is active in social media. She had recently[when?] conducted a question and answer session in Twitter. According to a survey conducted in July 2015, Karki is the highest followed Nepalese celebrity on Instagram
A survey conducted by Kantipur Saptahik on February 2016 ranked Karki as the most attractive woman in Nepal.
Right after winning Miss Teen Nepal 2005, she appeared on the cover of Wave Magazine. She has also appeared on the covers of Nari, Vivacity Magazine, ECS Living, Folio, WOW, Healthy living and Yuwa Manch. She has also been featured in the center page blow up of Kantipur Publications Saptahik and also numerous features on the weekly newsletter Friday by ECS. Karki is also an active participant as showstoppers for various fashion shows in K-town. During Trendsetters in September 2012. organized by Vootoo Entertainment, she walked as show stopper for the ace designer Subexya Bhadel. During Trendsetters II in May 2013, Karki gave a spectacular aerial dance performance to kick-start the show and later also show stopped for new designer Surochira. Karki showstopped for Vishal Kapoor wearing a creation from his collection ‘Bollywood’ at The Himalayan Times Nepal Fashion Week 2013. According to a survey done by Folio Magazine, Karki has been voted as the 4th sexiest woman in Nepal in 2013.